Don't put every question in one thread.
Splitting reduces context contamination.
Create projects and group related conversations under them. Projects support descriptions and instructions that are inherited by conversations inside them.
Favorite any AI reply from its more-actions menu for easy access later.
Create a branch from any message to explore different directions without affecting the original thread.
This order tends to work well:
BotHub stores your data locally by default. When signed in, conversations and settings (including API keys) sync to the cloud. When you call an online model, message content is sent to that provider. Check provider policies before sending sensitive data.